Immune Deficiencies
Bruton's
- no receptors on B cells, can't make antibodies
- encapsulated bacteria
- enterovirus enter through GI track
IgA Deficiency
CVID
- rare disorders in one disorders with variable degrees of deficiency
- immune dysregulation: autoimmune
DiGeorge
- similar to end stage HIV
- improve with age, may mature in other locations
- cleft palate, mandible: 3rd/4th pharyngeal pouches
Hyper-IgE
CMCC
- autoimmune T cell attack endocrine glands
SCID
- loss of entire adaptive immune system
- live in a bubble
- low CD3, low Ig levels
- can't do T cell count
- do TRECs
ADA
Ataxia
Hyper-IgM
Wiskott
- immunologic synapse: way T react to APC
- low or normal IgG/IgM. Elevated IgE/A
- bleeding/petechiae unique
Innate
LAD
- neutrophils can't get to stump
Chediak Higashi
- unique: oculocutaneous albinism
- melanocyte granules can't be transferred
CGD
- catalase breaks down H2O2
- catalase - can't break down H2O2
- Burkhoderia capacia
Backlinks